Research Journal of Pharmaceutical Dosage Form and Technology

P. S. Gangane ¹, K. G. Mahajan ¹, H. S. Sawarkar ¹, R. R. Thenge ¹, V. S. Adhao ¹

Affiliations
1 College of Pharmacy, Malkapur, Dist. – Buldana, Maharashtra, IN

Abstract

Gatifloxacin Sesquihydrate is a Broad Spectrum Antimicrobial agent active against Gram Positive and Gram Negative Organism. It is slightly bitter in taste. In the present study an attempt has been made to prepare bitterless fast dissolving tablet of Gatifloxacin Sesquihydrate using Indion 204, Indion 214, Indion 234, Tulsion 335 (ion exchange resin) as a taste masking agent. X-ray powder diffractometry, FT-IR spectroscopy and differential scanning calorimetry were used to investigate the physical characteristics of the crystals. The tablet was prepared by Wet granulation technique with three super disintegrants e.g. sodium starch glycolate, crosscarmellose sodium and crospovidone. The granules were examined for angle of repose, bulk density, tapped density and hausner’s ratio. The tablets were evaluated for hardness, drug content and friability and disintegration time. The disintegration in oral cavity was also tested and was found to be 22 sec. Also In-Vivo and In-Vitro taste Evaluation of Solid Drug: Resin Complex was carried out.

Keywords

Fast Dissolving Tablet, Gatifloxacin Sesquihydrate, Ion Exchange Resin, Super Disintegrants.

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N. M. Bhopale ¹, H. S. Sawarkar ², M. B. Narkhede ², N. V. Thorat ², M. R. Bhise ², S. S. Khadabadi ³

Affiliations
1 IBSS College of Pharmacy, Nimbari Phata, Buldana Road, Malkapur, Dist- Buldana-443 101, IN
2 I.B.S.S. College of Pharmacy, Malkapur- 443 101 (M.S.), IN
3 Govt. College of Pharmacy, Amravati-444 603 (M.S.), IN

Abstract

The purpose of the present investigation was to develop the sustain release matrix tablet of Tinospora cordifolia using the various polymers like HPMC (Hydroxy-Propyl-methyl-cellulose), Ethyl cellulose (EC), of different viscosity grade. Ethanolic extract of Tinospora cordifolia was used for the formulation of sustain release matrix tablet and tablet formulations were developed by using wet granulation method. Different diluents like lactose, magnesium stearate and cab-o-sil were used for improving flowability and compressibility. Binder such as polyvinyl pyrrolidone was used for optimization of the formulations. Sodium starch glycolate was used as disintegrating agent. Pre and post formulation parameters were studied for all the batches. HPMC –KM4 shows better result for matrix tablet in terms of sustain drug release with comparison to different viscosity grade of HPMC and ethyl cellulose. The dissolution study of the Tinospora cordifolia tablets exhibited 99.54% release of total polyphenol.

Keywords

Ethanolic Extract of Tinospora Cordifolia, HPMC, Ethyl Cellulose, Matrix Tablet.

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